p53 (17p13) / MPO (17q22) "ISO 17q"

Isochromosome 17q is the most common isochromosome in cancer. It plays an important role in tumor development and progression. Hematologic malignancies such as chronic myeloid leukemia (CML) with isochromosome 17q carry a poor prognosis. Isochromosome 17q is the most common chromosome abnormality in primitive neuroectodermal tumors and medulloblastoma. Isochromosome 17q is, by convention, symbolized as i(17q).

The p53 (17p13) & MPO (17q22) specific DNA Probe is optimized to detect copy numbers of the p53 gene region at 17p13 and MPO gene region at 17q22. In case of i(17q) a signal pattern of three red signals for MPO (17q22) and one signal for p53 at 17p13 is expected.

Cat.# KBI-10011 p53 (17p13) / MPO (17q22) "ISO 17q"

p53 (17p13) / MPO (17q22) "ISO 17q" hybridized to a normal
metaphase (2R2G).

Literature:
Becher et al. 1990, Blood, 75: 1679-1683.
Fioretos et al. 1999, Blood, 94: 225-232.

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