ATM (11q22)
Chromosome 11q22.3-23.1 deletions involving the ataxia-teleangiectasia mutated (ATM) locus are detected at diagnosis in 15-20% of cases of B-cell chronic lymphocytic leukemia (CLL) and are associated with a relatively aggressive disease. Loss of the 11q22-23 region, where the ataxia-telangiectasia mutated (ATM) gene is located is also one of the most frequent secondary chromosomal aberrations in mantle cell lymphoma.
The ATM (11q22.3) specific DNA Probe is optimized to detect copy numbers of the ATM gene region at region 11q22.3.
The Chromosome 11 Satellite Enumeration Probe is included to facilitate chromosome identification.
Cat.# KBI-10103 ATM (11q22) / SE 11
ATM (11q22) / SE 11 hybridized to patient material showing a
11q22 deletion at the ATM gene region (1R2G).
Image kindly provided by Dr Wenzel, Basel
Literature:
Doehner et al. 1997, Blood, 89: 2516-2522.
Bigoni et al. 1997, Leukemia, 11: 1933-1940.