PreimpScreen PolB is designed for determining chromosome copy number in polar bodies. The first polar body is removed from the unfertilized oocyte, and the second polar body from the zygote, shortly after fertilization. The main advantage of the use of polar bodies in preimplantation genetic screening (PGS) is that they are not necessary for successful fertilization or normal embryonic development, thus ensuring no deleterious effect for the embryo. In some countries, where the legislation bans the selection of preimplantation embryos, polar body analysis is the only possible method to perform PGS. The biopsy and analysis of the first and second polar bodies can be completed before syngamy, which is the moment from which the zygote is considered an embryo and becomes protected by the law.
Pseudo color image using PreimpScreen PolB (KBI-40050) on a metaphase spread from lymphocytes showing 2 signals each of chromosomes 13, 16, 18, 21, and 22, respectively.
PreimpScreen PolB is designed for determining chromosome copy number in polar bodies. The first polar body is removed from the unfertilized oocyte, and the second polar body from the zygote, shortly after fertilization. The main advantage of the use of polar bodies in preimplantation genetic screening (PGS) is that they are not necessary for successful fertilization or normal embryonic development, thus ensuring no deleterious effect for the embryo. In some countries, where the legislation bans the selection of preimplantation embryos, polar body analysis is the only possible method to perform PGS. The biopsy and analysis of the first and second polar bodies can be completed before syngamy, which is the moment from which the zygote is considered an embryo and becomes protected by the law.
Pseudo color image using PreimpScreen PolB (KBI-40050) on a metaphase spread from lymphocytes showing 2 signals each of chromosomes 13, 16, 18, 21, and 22, respectively.