The cytogenetic picture in multiple myeloma (MM) is highly complex, from which non-random numerical and structural chromosomal changes have been identified. Specifically, translocations involving the immunoglobulin heavy chain gene (IGH) at 14q32 and either monosomy or deletions of chromosome 13 have been observed in a significant number of patients. More recently several additional deletions or amplifications have been identified in MM which are currently investigated in large patient studies.

Note: Multiple Myeloma is a cancer of plasma cells. Analysis of such cells is hampered by their low frequency. Enrichment of plasma cells using CD138 is highly recommended.

The cytogenetic picture in multiple myeloma (MM) is highly complex, from which non-random numerical and structural chromosomal changes have been identified. Specifically, translocations involving the immunoglobulin heavy chain gene (IGH) at 14q32 and either monosomy or deletions of chromosome 13 have been observed in a significant number of patients. More recently several additional deletions or amplifications have been identified in MM which are currently investigated in large patient studies.

Note: Multiple Myeloma is a cancer of plasma cells. Analysis of such cells is hampered by their low frequency. Enrichment of plasma cells using CD138 is highly recommended.