Acute lymphocytic leukemia, also called acute lymphoblastic leukemia, is a type of cancer that starts from white blood cells in the bone marrow. A number of recurring cytogenetic abnormalities are associated with distinct immunologic phenotypes of ALL and characteristic outcomes. The ETV6/AML1 fusion arising from the translocation
t(12;21)(p13;q22) has been associated with a good outcome; the BCR/ABL fusion of
t(9;22)(q34;q11), rearrangements of the MLL gene (11q23), and abnormalities of the short arm of chromosomes 9 involving the tumor suppressor genes p16 (INK4A) have a poor prognosis.
Acute lymphocytic leukemia, also called acute lymphoblastic leukemia, is a type of cancer that starts from white blood cells in the bone marrow. A number of recurring cytogenetic abnormalities are associated with distinct immunologic phenotypes of ALL and characteristic outcomes. The ETV6/AML1 fusion arising from the translocation
t(12;21)(p13;q22) has been associated with a good outcome; the BCR/ABL fusion of
t(9;22)(q34;q11), rearrangements of the MLL gene (11q23), and abnormalities of the short arm of chromosomes 9 involving the tumor suppressor genes p16 (INK4A) have a poor prognosis.