CLL accounts for about 30% of all leukemias in Europe and the USA. Distinct clonal chromosomal abnormalities can be identified in up to 90% of CLL cases of the B-cell lineage. By FISH the most common chromosomal changes in CLL and their frequencies have been identified as shown in the table below.
| Del(13q14) |
55% |
| Del(11q) |
18% |
| Trisomy 12q |
16% |
| Del(17p) |
7% |
| Del(6q) |
6% |
| Trisomy 8q |
5% |
| t(14q32) |
4% |
| Trisomy 3q |
3% |
CLL probe combinations
Most of the CLL probes are also available as combinations covering two critical loci in one hybridization. This is of particular interest if patient material is limited. The disadvantage is that no internal control is added.
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CLL accounts for about 30% of all leukemias in Europe and the USA. Distinct clonal chromosomal abnormalities can be identified in up to 90% of CLL cases of the B-cell lineage. By FISH the most common chromosomal changes in CLL and their frequencies have been identified as shown in the table below.
| Del(13q14) |
55% |
| Del(11q) |
18% |
| Trisomy 12q |
16% |
| Del(17p) |
7% |
| Del(6q) |
6% |
| Trisomy 8q |
5% |
| t(14q32) |
4% |
| Trisomy 3q |
3% |
CLL probe combinations
Most of the CLL probes are also available as combinations covering two critical loci in one hybridization. This is of particular interest if patient material is limited. The disadvantage is that no internal control is added.
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