Host: Mouse, Isotype: IgG₁, Clone: A103

FP RC

This monoclonal antibody binds to MART-1. In normal tissues, expression of MART-1 is found in human and murine melanocyte lineage cells derived from normal skin, uvea, and retina. Other normal tissues, including T cells, B cells, kidney epithelial cells, and fibroblasts, are negative. In tumors, MART-1 is expressed by a large proportion of melanomas, both melanotic and amelanotic, and by melanoma cell lines. The antigen is not detectable in non-melanoma malignancies, including neoplasms of colon, breast, brain, kidney, lung, and bone. 
Immunogen source: MART-1 fusion protein. Positive tissue: Melanoma. Expected staining pattern: Cytoplasmic.

MART-1 (Melan-A)

Host: Mouse, Isotype: IgG₁, Clone: A103
Host: Mouse, Isotype: IgG_2b, Clone: M2-7C10
Host: Mouse, Isotype: IgG_2b, Clone: M2-9E3

FP RC

Mouse anti-MART-1 stained melanoma.

This monoclonal antibody cocktail binds to MART-1. In normal tissues, expression of MART-1 is found in human and murine melanocyte lineage cells derived from normal skin, uvea, and retina. Other normal tissues, including T cells, B cells, kidney epithelial cells, and fibroblasts, are negative. In tumors, MART-1 is expressed by a large proportion of melanomas, both melanotic and amelanotic, and by melanoma cell lines. The antigen is not detectable in non-melanoma malignancies, including neoplasms of colon, breast, brain, kidney, lung, and bone. 
Immunogen source: MART-1 fusion protein. Positive tissue: Melanoma. Expected staining pattern: Cytoplasmic.

Host: Mouse, Isotype: IgG₁, Clone: A103

FP RC

This monoclonal antibody binds to MART-1. In normal tissues, expression of MART-1 is found in human and murine melanocyte lineage cells derived from normal skin, uvea, and retina. Other normal tissues, including T cells, B cells, kidney epithelial cells, and fibroblasts, are negative. In tumors, MART-1 is expressed by a large proportion of melanomas, both melanotic and amelanotic, and by melanoma cell lines. The antigen is not detectable in non-melanoma malignancies, including neoplasms of colon, breast, brain, kidney, lung, and bone. 
Immunogen source: MART-1 fusion protein. Positive tissue: Melanoma. Expected staining pattern: Cytoplasmic.

MART-1 (Melan-A)

Host: Mouse, Isotype: IgG₁, Clone: A103
Host: Mouse, Isotype: IgG_2b, Clone: M2-7C10
Host: Mouse, Isotype: IgG_2b, Clone: M2-9E3

FP RC

Mouse anti-MART-1 stained melanoma.

This monoclonal antibody cocktail binds to MART-1. In normal tissues, expression of MART-1 is found in human and murine melanocyte lineage cells derived from normal skin, uvea, and retina. Other normal tissues, including T cells, B cells, kidney epithelial cells, and fibroblasts, are negative. In tumors, MART-1 is expressed by a large proportion of melanomas, both melanotic and amelanotic, and by melanoma cell lines. The antigen is not detectable in non-melanoma malignancies, including neoplasms of colon, breast, brain, kidney, lung, and bone. 
Immunogen source: MART-1 fusion protein. Positive tissue: Melanoma. Expected staining pattern: Cytoplasmic.

                                                                                                                                  
Sample preparation:
P = Formalin-fixed, parafin-embedded 
F = Frozen (cryostat) sections 
A = Alcohol-fixed, paraffin-embedded 
C = Cell preparation

Enhancement methods:
* = May enhance staining
1 = Digest-All™ 1 required
2 = Digest-All™ 2 required 
3 = Digest-All™ 3 required

HIER Enhancement methods:
RC = Heat Induces Epitope Retrieval using citrate buffer (HIER, pH 6.0)
RE = Heat Induced Epitope Retrieval using EDTA (HIER, pH 8.0)

                                                                                                                                  
Sample preparation:
P = Formalin-fixed, parafin-embedded 
F = Frozen (cryostat) sections 
A = Alcohol-fixed, paraffin-embedded 
C = Cell preparation

Enhancement methods:
* = May enhance staining
1 = Digest-All™ 1 required
2 = Digest-All™ 2 required 
3 = Digest-All™ 3 required

HIER Enhancement methods:
RC = Heat Induces Epitope Retrieval using citrate buffer (HIER, pH 6.0)
RE = Heat Induced Epitope Retrieval using EDTA (HIER, pH 8.0)

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