HER2 (c-erbB-2) Extracellular Domain

Host: Mouse, Isotype: IgG1, Clone: TAB250 1

 

Mouse anti-HER2 stained tissue.

HER2, also known as c-erbB-2 or Neu, is a member of the epidermal growth factor receptor family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. The cytoplasmic domain contains a tyrosine kinase that is activated by ligand-induced dimerization of the receptor. This family of receptors is important in regulating cell growth. 
Immunogen source: NIH 3T3 cells transfected with c-erbB-2.

1. Langton B.C., et al. Cancer Res 51: 2593-2598 (1991).

HER2 (c-erbB-2) Intracellular Domain

Host: Mouse, Isotype: IgG1, Clone: CB11

This monoclonal antibody reacts with the intracellular domain of HER2. HER2 is a tyrosine kinase transmembrane receptor. 
Immunogen source: Synthetic peptide corresponding to an intracellular sequence of human HER2.

HER2 (c-erbB-2) Intracellular Domain

Host: Rabbit

This polyclonal antibody reacts with the intracellular domain of HER2. HER2 is a tyrosine kinase transmembrane receptor. Immunogen source: Synthetic peptide corresponding to a cytoplasmic segment of human HER2.

Host: Mouse, Isotype: IgG1, Clone: TAB250 1

 

Mouse anti-HER2 stained tissue.

HER2, also known as c-erbB-2 or Neu, is a member of the epidermal growth factor receptor family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. The cytoplasmic domain contains a tyrosine kinase that is activated by ligand-induced dimerization of the receptor. This family of receptors is important in regulating cell growth. 
Immunogen source: NIH 3T3 cells transfected with c-erbB-2.

1. Langton B.C., et al. Cancer Res 51: 2593-2598 (1991).

HER2 (c-erbB-2) Intracellular Domain

Host: Mouse, Isotype: IgG1, Clone: CB11

This monoclonal antibody reacts with the intracellular domain of HER2. HER2 is a tyrosine kinase transmembrane receptor. 
Immunogen source: Synthetic peptide corresponding to an intracellular sequence of human HER2.

HER2 (c-erbB-2) Intracellular Domain

Host: Rabbit

This polyclonal antibody reacts with the intracellular domain of HER2. HER2 is a tyrosine kinase transmembrane receptor. Immunogen source: Synthetic peptide corresponding to a cytoplasmic segment of human HER2.

   
Products
Product Quantity Cat. no.
HER2 (c-erbB-2) Extracellular Domain - Host: Mouse, Isotype: IgG1, Clone: TAB250
2ndGen Predilute for Histology 6 ml 08-1203
V-Line Predilute 10 ml 08-4203
Concentrate for Histology 1 ml 28-0003Z
HER2 (c-erbB-2) Intracellular Domain - Host: Mouse, Isotype: IgG1, Clone: CB11
Predilute for Histology 6 ml 08-0107
Concentrate for Histology 0.5 ml 18-7107
HER2 (c-erbB-2) Intracellular Domain - Host Rabbit
2ndGen Predilute for Histology 6 ml 08-1204
Concentrate for Histology 1 ml 28-0004
Product Quantity Cat. no.
HER2 (c-erbB-2) Extracellular Domain - Host: Mouse, Isotype: IgG1, Clone: TAB250
2ndGen Predilute for Histology 6 ml 08-1203
V-Line Predilute 10 ml 08-4203
Concentrate for Histology 1 ml 28-0003Z
HER2 (c-erbB-2) Intracellular Domain - Host: Mouse, Isotype: IgG1, Clone: CB11
Predilute for Histology 6 ml 08-0107
Concentrate for Histology 0.5 ml 18-7107
HER2 (c-erbB-2) Intracellular Domain - Host Rabbit
2ndGen Predilute for Histology 6 ml 08-1204
Concentrate for Histology 1 ml 28-0004
   
 

                                                                                                                                  
Sample preparation:
P = Formalin-fixed, parafin-embedded 
F = Frozen (cryostat) sections 
A = Alcohol-fixed, paraffin-embedded 
C = Cell preparation

Enhancement methods:
* = May enhance staining
1 = Digest-All™ 1 required
2 = Digest-All™ 2 required 
3 = Digest-All™ 3 required

HIER Enhancement methods:
RC = Heat Induces Epitope Retrieval using citrate buffer (HIER, pH 6.0)
RE = Heat Induced Epitope Retrieval using EDTA (HIER, pH 8.0)

                                                                                                                                  
Sample preparation:
P = Formalin-fixed, parafin-embedded 
F = Frozen (cryostat) sections 
A = Alcohol-fixed, paraffin-embedded 
C = Cell preparation

Enhancement methods:
* = May enhance staining
1 = Digest-All™ 1 required
2 = Digest-All™ 2 required 
3 = Digest-All™ 3 required

HIER Enhancement methods:
RC = Heat Induces Epitope Retrieval using citrate buffer (HIER, pH 6.0)
RE = Heat Induced Epitope Retrieval using EDTA (HIER, pH 8.0)