ONE LABELING Technology for all Microarray and FISH Applications
The proprietary ULS (Universal Linkage System) technology provides the basis for KREATECH’s broad range of labeling applications. ULS labeling is based on the stable coordinative binding properties of platinum to nucleic acids and proteins. The ULS molecule consists of a platinum complex, a detectable molecule and a leaving group which is displaced upon reaction with the target. This reaction results in a coordinative bond, firmly coupling the ULS to the target. ULS labels DNA and RNA by binding to the N7 position of guanine. In proteins, ULS binds to sulfur and nitrogen containing side chains of methionine, cysteine and histidine. ULS is available coupled to a variety of labels and haptens, including fluorochromes and biotin. The labeling reaction allows a wide range of conditions and produces a highly stable bond.
Principle of the ULS technology
Targets labeled with ULS
| Nucleic Acids |
Proteins |
| Guanine |
Methionine, Cysteine, Histidine |
ULS labels DNA and RNA by forming a
coordinative bond
on the N7 position
of guanine |
ULS labels proteins by forming
a coordinative bond on the
sulfur atoms of methionine,
cysteine and the nitrogen atom
of histidine |
Unique features of the ULS Labeling Technology
- Time saving: Entire labeling procedure in only 30 minutes for DNA and 15 min for RNA
- Easy to use
- Robust and reproducible – no enzymes involved
- Superior labeling technology for FFPE samples
- One technology for all applications
- Compatible with all microarray platforms
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ONE LABELING Technology for all Microarray and FISH Applications
The proprietary ULS (Universal Linkage System) technology provides the basis for KREATECH’s broad range of labeling applications. ULS labeling is based on the stable coordinative binding properties of platinum to nucleic acids and proteins. The ULS molecule consists of a platinum complex, a detectable molecule and a leaving group which is displaced upon reaction with the target. This reaction results in a coordinative bond, firmly coupling the ULS to the target. ULS labels DNA and RNA by binding to the N7 position of guanine. In proteins, ULS binds to sulfur and nitrogen containing side chains of methionine, cysteine and histidine. ULS is available coupled to a variety of labels and haptens, including fluorochromes and biotin. The labeling reaction allows a wide range of conditions and produces a highly stable bond.
Principle of the ULS technology
Targets labeled with ULS
| Nucleic Acids |
Proteins |
| Guanine |
Methionine, Cysteine, Histidine |
ULS labels DNA and RNA by forming a
coordinative bond
on the N7 position
of guanine |
ULS labels proteins by forming
a coordinative bond on the
sulfur atoms of methionine,
cysteine and the nitrogen atom
of histidine |
Unique features of the ULS Labeling Technology
- Time saving: Entire labeling procedure in only 30 minutes for DNA and 15 min for RNA
- Easy to use
- Robust and reproducible – no enzymes involved
- Superior labeling technology for FFPE samples
- One technology for all applications
- Compatible with all microarray platforms
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