We are pleased to announce the introduction of the entire series of Arm Specific Probes (ASP). These probes hybridize to unique sequences comprising either p- or q-arms of all human chromosomes (except the p-arm of the acrocentric chromosomes), and they span the entire length of the respective chromosome arm. They are derived from flow-sorted or microdissected chromosomes, to be highly specific for each chromosome.
ASP applications permit the detection of chromosomal aberrations at the resolution of chromosome arms. Their use in molecular cytogenetic examinations of patients include analysis of chromosome partners involved in translocations; identification of the chromosome of origin of marker chromosomes; analyses of complex chromosomal rearrangements in neoplastic cells and identification of inborn supernumerary marker chromosome, as well as confirmation of results obtained from M-FISH and SKY testing. ASP may be of particular interest to those studying mutagenesis of human chromosomes, for instance as a result of exposure to genotoxic agents. Our Arm Specific Probes are supplied in a ready-to-use format, and are available in two colors of choice: green and red.
Band Specific Probes
Rearrangements affecting regions smaller than an average G-band can be visualized using band-specific FISH probes. These particular probes enhance the resolution typically obtained with whole chromosome probes when identifying chromosomal abnormalities. Band-Specific probes are capable of detecting small chromosomal segments, such as those involved in subtle translocations with breakpoints localized in distinct bands. They are
amplified from microdissected chromosome material and fluorescently labeled to allow detection of these subchromosomal regions. KREATECH is pleased to introduce custom service for manufacturing such Band-Specific probes of your choice.
We are pleased to announce the introduction of the entire series of Arm Specific Probes (ASP). These probes hybridize to unique sequences comprising either p- or q-arms of all human chromosomes (except the p-arm of the acrocentric chromosomes), and they span the entire length of the respective chromosome arm. They are derived from flow-sorted or microdissected chromosomes, to be highly specific for each chromosome.
ASP applications permit the detection of chromosomal aberrations at the resolution of chromosome arms. Their use in molecular cytogenetic examinations of patients include analysis of chromosome partners involved in translocations; identification of the chromosome of origin of marker chromosomes; analyses of complex chromosomal rearrangements in neoplastic cells and identification of inborn supernumerary marker chromosome, as well as confirmation of results obtained from M-FISH and SKY testing. ASP may be of particular interest to those studying mutagenesis of human chromosomes, for instance as a result of exposure to genotoxic agents. Our Arm Specific Probes are supplied in a ready-to-use format, and are available in two colors of choice: green and red.
Band Specific Probes
Rearrangements affecting regions smaller than an average G-band can be visualized using band-specific FISH probes. These particular probes enhance the resolution typically obtained with whole chromosome probes when identifying chromosomal abnormalities. Band-Specific probes are capable of detecting small chromosomal segments, such as those involved in subtle translocations with breakpoints localized in distinct bands. They are
amplified from microdissected chromosome material and fluorescently labeled to allow detection of these subchromosomal regions. KREATECH is pleased to introduce custom service for manufacturing such Band-Specific probes of your choice.